How Does Genetics Influence Celiac Disease-sweets parade

Health A lifelong avoidance of gluten foods is what every person with celiac disease must do. There are no remedies; just that: absolute gluten-free lifestyle. Even a slight contamination of the food can cause severe signs and symptoms. The disease is an autoimmune disorder that is genetically linked. This means that the immune system malfunctions and attacks the bodys own tissues and organs. By far, that is how celiac disease is related to genetics and explained. For Celiacs disease, however, this is not enough. One is nagged with curiosity and the need to understand why one must have to avoid gluten throughout life. Thus, the question: How does genetics influence Celiac disease? The Beginning Of The puzzle When people, especially babies, start showing recurring signs and symptoms, which give doctors a hard time diagnose, the puzzle begins. When doctors suspect that an infant or a young child could be Celiac, the medical history of the family becomes the focus and is regarded as one of the most important information that can establish diagnosis. With much of the signs and symptoms being nonspecific (common to several kinds of medical conditions) and some patients being asymptomatic, the diagnosis and confirming the prognosis are not so easy to do. The discovery of another Celiac in the family is a breakthrough; not because it will prompt treatment (because there is none), but because it can signal the start of lifelong gluten-free lifestyle for the afflicted and perhaps for the entire family. Having relatives who are Celiac can lead a doctor to do more clinical testing to confirm the conditions. The discovery of Celiac disease relative is a breakthrough because Celiac is hereditary or genetic. The anomaly is in the genes which is why a corrective treatment cannot be done. The only treatment is the management of the lifestyle as early as possible before much serious damage is done on the intestinal linings resulting to the triggering of several complications. Early diagnosis can also prevent the misfortune of ingesting gluten leading to untoward consequences. Inheriting Celiac Disease So, Celiac disease is related to a genetic predisposition with signs and symptoms that are unleashed with the ingestion of gluten from wheat, barley, rye and (oats due to contamination). Recent studies identified the genes that are responsible for this genetic predisposition. Celiac disease is noted to be associated with certain specific HLA class II genes, namely: HLA-DQ2 and HLADQ8. These are both found in chromosome p21. HLA-DQ2 is responsible for about 95 percent of the Celiac disease cases known while the rest are generally carriers of HLA-DQ8 positive. The former is common and can be found in about 30 percent of the Caucasians. To be Celiac, one need to have either the HLA-DQ2 or HLA-DQ8, but it is not enough for the disease or for the signs and symptoms to develop. Studies revealed that for Celiac disease to develop, a person need to have one or both of two genes (HLA-DQ2 and HLA-DQ8) and the triggering by a major environmental factor like gluten ingestion. Gluten protein called gliadin can induce an abnormal immune response that leads to damages in the microvilli found in the lining of the small intestine. Triggering factors are needed such as the exposure to gluten. Environmental events like infection and pregnancy are now being regarded as possible factors that can wake up the genetic predisposition (estimated to be about 36 to 53 percent). Some Celiacs report that accidents too can trigger the manifestations. This is believed to be true in some studies but cant be proven. The Bottom Line To have any of these two Celiac genes means that the person is predisposed to developing Celiac disease or has the higher risk of developing the disease; yet, not everyone who has the gene actually have Celiac disease. The severity of the signs and symptoms are, to a large extent, hard to predict too. These days, genetic tests are available to ascertain the presence of HLA-DQ2 or HLA-DQ8 and a persons predisposition to the disease. It does not test for the presence of the disease already; it only means that people with the genes can have sensitivity to gluten as well as the related manifestations. More recent genetic studies are surveying the genetic architecture to validate the loci (specific location of DNA sequence) that are associated with other immune-mediated diseases. About 13 new risk loci for Celiac disease have been identified in single genes or regulatory genes. Though each of these may not significantly define a Celiac disease trait, these add up to the growing information about Celiac disease. Such knowledge can, hopefully, promise treatments for Celiac patients. About the Author: 相关的主题文章:

« »

Comments closed.